Types of drugs that interact with metoprolol include antidepressants including bupropion wellbutrin , fluoxetine prozac, sarafem , and paroxetine paxil antimalaria drugs such as hydroxychloroquine medications used to treat heartburn or other stomach conditions, such as cimetidine tagamet and ranitidine zantac some heart medications, including clonidine catapres , propafenone rythmol…