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All prescription nsaids like celebrex, ibuprofen, naproxen and meloxicam have the same cardiovascular warning.

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Celecoxib can pass into breast milk and may harm a nursing babyTell your doctor if you are breast-feeding a baby.

Advise females of reproductive potential who desire pregnancy that NSAIDsincluding CELEBREXmay be associated with a reversible delay in ovulationsee Use In Specific Populations

A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polypsseverepotentially fatal bronchospasmand/or intolerance to aspirin and other NSAIDsBecause cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patientsCELEBREX is contraindicated in patients with this form of aspirin sensitivitysee CONTRAINDICATIONSWhen CELEBREX is used in patients with preexisting asthmawithout known aspirin sensitivitymonitor patients for changes in the signs and symptoms of asthma.

Inhibition of PGE2 synthesis may lead to sodium and water retention through increased reabsorption in the renal medullary thick ascending loop of Henle and perhaps other segments doxycycline order cheap of the distal nephronIn the collecting ductsPGE2 appears to inhibit water reabsorption by counteracting the action of antidiuretic hormone.

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