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Drugs which may affect leukocyte productionincluding cotrimoxazolemay lead to exaggerated leukopeniaespecially in renal transplant recipients.
Patients receiving immunosuppressive therapyincluding azathioprine are at an increased risk of developing lymphoproliferative disorders and other malignanciesnotably skin cancersmelanoma and non-melanomasarcomasKaposi’s and non-Kaposi’sand uterine cervical cancer in situThe increased risk appears to be related to the degree and duration of immunosuppressionIt has been reported that discontinuation of immunosuppression may provide partial regression of the lymphoproliferative disorder.
Maintenance dosage should range from 1 to 4 mg/kg bodyweight/day and must be adjusted doxycyclin cheapest according to clinical requirements and haematological tolerance.
Symptoms of an allergic reaction usually happen within the first few weeks of treatmentThey include:
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